American Nurses Credentialing Center (ANCC) Practice Exam 2025 – Comprehensive All-in-One Guide for Exam Success!

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Why is a progestational medication administered to perimenopausal women who use estrogen?

Preventing hot flashes.

Preventing osteoporosis.

Promoting growth of the uterine lining.

Decrease the risk of endometrial hyperplasia.

Progestational medications are administered to perimenopausal women who use estrogen primarily to decrease the risk of endometrial hyperplasia. When estrogen is used in hormone therapy, it can lead to excessive proliferation of the uterine lining (the endometrium). This excessive growth can result in endometrial hyperplasia, which is a condition that increases the risk of developing endometrial cancer. By introducing a progestational agent, the effects of estrogen are counteracted, promoting a normal shedding of the uterine lining and reducing the likelihood of hyperplasia. This is a critical preventive measure in managing the hormonal balance in women undergoing perimenopause or hormone replacement therapy.

The other options present potential benefits or concerns related to hormone therapy, but they do not directly address the primary reason for co-administering a progestational agent with estrogen in this context.

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